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In Vivo Degradation of Collagen Barrier Membranes Exposed to the Oral Cavity

Klinger A, Asad R, Shapira L, Zubery Y.
Clin Oral Implants Res. 2010 Aug;21(8):873-6.

PubMed PMID: 20666799

The purpose of this human clinical trial was to compare the degradation profiles of three different collagen membranes under conditions mimicking exposure to the oral cavity.
Three collagen membranes, ribose cross-linked (RCL), glutaraldehyde cross-linked (GCL), and non-cross-linked (NCL) were tested. The membranes were placed over the buccal mucosa of 20 human volunteers, apical to the gingival margins in the maxillary premolar and molar region. A periodontal dressing was placed over the membranes and secured in the interproximal spaces. The dressing was removed after 10 days, and membrane integrity was evaluated by two examiners using a Likert-like grading scale (grades 1-5).
Eight subjects withdrew from the study due to discomfort, pain, or dislodging of the pack. Of the three membranes tested, RCL appeared to be the most resistant to degradation (median grade 5), compared with GCL (2.25) and NCL (1.75).
Marked differences in membrane integrity were found between the three tested membranes after 10 days in the oral cavity. These differences may be part of the important factors determining the outcome of the regenerative treatment modality in cases of premature membrane exposure.


Datum Dental Ltd is a subsidiary company of Datum Biotech. The Company was created in order to develop, manufacture and market a full line of dental biomaterials for tissue and bone regeneration.

Datum Biotech Ltd is an Israeli based Biomaterials company that specializes in developing, manufacturing and commercializing proprietary technologies, which are based on innovative and unique sugar cross-linked collagen products for tissue engineering and regenerative medicine.
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